Prospective analysis of gender-related characteristics in relation to cardiovascular disease

Abstract Background Cardiovascular diseases (CVD) are a major public health problem in men and women worldwide. Differences CVD incidence between have been widely reported, although explanations for these differences remain unclear. Next to sex-related (biological) characteristics, gender-related (sociocultural) characteristics may partly explain how arise. We aimed establish the associations selected incidence. Methods linked baseline data of 18,058 participants without from population-based, multi-ethnic HELIUS study (Amsterdam, Netherlands) data, based on hospital admission death records Statistics Netherlands 2013-2018. Using Cox regression analyses, we studied time spent household work, doing home repairs, primary earner status, type employment, performing male-dominated or female-dominated occupation, desire emotional support with incidence, overall (with adjustment sex) stratified by sex. Analyses were adjusted age, ethnicity, socioeconomic status. Results In fully most not associated higher among men. women, homemakers had hazard compared fulltime workers (hazard ratio [HR] 2.34, 95% confidence interval [CI] 1.35-4.04), whereas those spending moderate amount work lower than little (HR 0.56, CI 0.34-0.95). Conclusions Although men, being homemaker women. Thus, attention future help identify subgroups that benefit additional prevention strategies. Key messages Some relevant cardiovascular disease risk, particularly Attention